Extended TNF Genotyping Identifies TNF -857T as a Risk Factor for Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation.
Charles Mullighan, Sue L Heatley, Natalie R Villalta, Kathleen V Doherty, Silke Danner, Uwe Hahn, Kenneth Bradstock, Anthony P Schwarer, Jeffrey Szer, Peter G Bardy
Blood | American Society of Hematology | Published : 2006
Abstract Extensive evidence supports a role for non-HLA immunogenetic polymorphisms in determining risk and severity of acute GVHD following allogeneic hematopoietic stem cell transplantation (HCT). Tumor necrosis factor (TNF) polymorphisms have been frequently associated with GVHD risk. However, TNF is highly polymorphic and the TNF polymorphism(s) most strongly associated with GVHD remain to be determined. We previously studied three TNF single nucleotide polymorphisms (SNPs; −308, −238 and 488) in a retrospective study of 160 myeloablative HLA-matched related allo-HCTs and found a highly significant association between the intronic TNF 488A allele and risk and severity of a..View full abstract