Journal article

Complement Factors in COVID-19 Therapeutics and Vaccines

Liriye Kurtovic, James G Beeson

Trends in Immunology | ELSEVIER SCI LTD | Published : 2021

Abstract

Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been overshadowed by reports of extensive complement activation in severe coronavirus disease 2019 (COVID-19) patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The authors were supported by funding from the National Health and Medical Research Council of Australia (grants 1173046, 1092789). Burnet Institute is supported by the NHMRC Independent Research Institute Infrastructure Support Scheme and a Victorian State Government Operational Infrastructure grant.