Conference Proceedings

SUN-127 Diagnostic Challenges Associated with the Rising Incidence of Endocrine Toxicity in the Era of Combination Immunotherapy

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Journal of the Endocrine Society | The Endocrine Society | Published : 2020

Abstract

Abstract Background: Immune checkpoint blockade is now established as standard of care in several malignancies. Trials involving combined cytotoxic T lymphocyte associated protein 4 (CTLA4) and programmed cell death protein 1 (PD1) blockade demonstrate improved tumour responses in melanoma but at the cost of severe grade 3-4 immune related adverse events (irAEs) in 55%, and endocrine irAEs in up to 10% [1]. Immune-mediated damage to endocrine glands can be a diagnostic and management challenge. We aimed to review the incidence, biochemical evolution and imaging findings of endocrine toxicity related to combined anti CTLA-4 and anti-PD-1 therapy. Methods: We undertook a retrosp..

View full abstract

Citation metrics