Journal article

pH - Responsive colloidal carriers assembled from beta-lactoglobulin and Epsilon poly-L-lysine for oral drug delivery

Naisarg Pujara, Rabina Giri, Kuan Yau Wong, Zhi Qu, Prarthana Rewatkar, Md Moniruzzaman, Jakob Begun, Benjamin P Ross, Michael McGuckin, Amirali Popat

JOURNAL OF COLLOID AND INTERFACE SCIENCE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021

Abstract

Site specific oral delivery of many biopharmaceutical classification system (BCS) class II and IV drugs is challenging due to their poor solubility, low permeability and degradation in the gastrointestinal tract. Whilst colloidal carriers have been used to improve the bioavailability of such drugs, most nanocarriers based drug delivery systems suffer from multiple disadvantages, including low encapsulation efficiency (liposomes, polymeric nanoparticles), complex synthesis methods (silica, silicon-based materials) and poorly understood biodegradability (inorganic nanoparticles). Herein, a novel pH responsive nanocolloids were self-assembled using natural compounds such as bovine β-lactoglobul..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

Authors are thankful for research maintenance funds provided by School of Pharmacy, The University of Queensland and funding provided by Mater Medical Research institute. Dr Popat is thankful to National Health and Medical Research Council of Australia for Career Development (GNT1146627), Early Career Fellowship (GNT1146627) and project grant. Authors are also thankful to Centre of Microscopy and Microanalysis (CMM) at UQ and TRI for providing facilities.