Journal article

Genome‐wide study of the human lipidome and links to Alzheimer’s disease risk

Peter J Meikle, Corey Giles, Gemma Cadby, Kevin Huynh, Natalie A Mellett, Gavriel Olshansky, Alexander Smith, Anh Nguyen, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin Show all

Alzheimer's & Dementia | Wiley | Published : 2020

Abstract

Background Dysregulation of lipid metabolism is as an important – and modifiable – risk factor for the initiation and progression of Alzheimer’s disease (AD). Although lipid metabolism is established as crucial to numerous biological processes, the genetic factors that influence inter‐individual variation are still not well understood. To address this issue, we apply an integrative approach to link genetic variants with altered lipid metabolism and AD. Method Lipidomic profiling was performed using liquid chromatography coupled electrospray‐ionization tandem‐mass spectrometry on 4,492 genotyped individuals from the Busselton Family Health Study. We performed genome‐wide association analysis..

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