Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4 T Cell Engulfment Process.
Scott P Davies, Gary M Reynolds, Alex L Wilkinson, Xiaoyan Li, Rebecca Rose, Maanav Leekha, Yuxin S Liu, Ratnam Gandhi, Emma Buckroyd, Joe Grove, Nicholas M Barnes, Robin C May, Stefan G Hubscher, David H Adams, Yuehua Huang, Omar Qureshi, Zania Stamataki
Cell Reports | Published : 2019
CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes. We term this phenomenon enclysis to reflect the specific enclosure of CD4+ T cells in hepatocytes. Enclysis is selective for CD4+ but not CD8+ cells, independent of antigen-specific activation, and occurs in human hepatocytes in vitro, ex vivo, and in vivo. Intercellular adhesion molecule 1 (ICAM-1) facilitates T cell early adhesion and internalization, whereas hepatocytes form membrane lamellipodia or blebs to mediate engulfment. T cell internalization is unaffected by wor..View full abstract
Awarded by Medical Research Council