Deconstructing depression and negative symptoms of schizophrenia; differential and longitudinal immune correlates, and response to minocycline treatment.
Carl R Krynicki, Paola Dazzan, Carmine M Pariante, Nicholas M Barnes, Rachel C Vincent, Alex Roberts, Annalisa Giordano, Andrew Watson, John Suckling, Thomas RE Barnes, Nusrat Husain, Peter B Jones, Eileen Joyce, Stephen M Lawrie, Shôn Lewis, Bill Deakin, Rachel Upthegrove, undefined BeneMin Study team
Brain Behavior and Immunity | Published : 2021
BACKGROUND: Immune dysfunction has been implicated in negative symptoms of schizophrenia and also in depression. These disorders are frequently co-morbid, with some symptoms such as anhedonia and apathy common to both. The anti-inflammatory agent minocycline may be ineffective in schizophrenia, but more positive effects have been seen in depression. Our aim was to investigate the role of immune dysfunction in depression and sub-domains of negative symptoms in schizophrenia by investigating their intercorrelation and the influence of treatment with minocycline. METHODS: We analysed longitudinal data from 207 patients within 5 years of onset of schizophrenia, from the randomised double-blind, ..View full abstract