Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer's disease.
NM Barnes, CH Cheng, B Costall, RJ Naylor, TJ Williams, CM Wischik
Eur J Pharmacol | Published : 1991
The present study assesses the binding density of the selective angiotensin converting enzyme (ACE) radioligand [3H]ceranapril in brain tissue homogenates derived from patients with Alzheimer's disease and those from age-, sex- and post-mortem delay-matched neurologically normal patients. Saturation studies with [3H]ceranapril identified that the specific binding (defined by captopril, 10 microM) was homogenous and of high affinity. ACE inhibitor recognition site density was higher by some 70% in the temporal cortex (Brodmann area 22) from Alzheimer's patients whereas densities were similar in frontal cortex and cerebellum when compared to control tissue. It is unknown whether this apparentl..View full abstract