Journal article

Antidepressant use and interpersonal violence perpetration: a protocol for a systematic review and meta-analysis

Claire Keen, James A Foulds, Melissa Willoughby, Giles Newton-Howes, Josh Knight, Seena Fazel, Rohan Borschmann, Stuart A Kinner, Jesse T Young

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2021

Abstract

INTRODUCTION: There are conflicting perspectives as to whether antidepressant medication increases, decreases or has no effect on violence perpetration, impulsivity and aggressive behaviour. This is an important question given the widespread use of antidepressant medication and the significant medical, social, legal and health consequences of violence. We aim to: (1) systematically identify observational studies and randomised controlled trials that quantify the relationship between antidepressant use and interpersonal violence; (2) assess the quality of studies that quantify the relationship between antidepressant use and interpersonal violence and (3) estimate the pooled prevalence and mea..

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Grants

Awarded by National Health and Medical Research Council Investigator Grant


Awarded by National Health and Medical Research Council Senior Research Fellowship


Funding Acknowledgements

JY receives salary and research support from a National Health and Medical Research Council Investigator Grant (NTG1178027). SAK receives salary and research support from a National Health and Medical Research DCouncil Senior Research Fellowship (GNT1078168). Apart from the funding sources acknowledged above, this research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.