Journal article

Degeneration of structural brain networks is associated with cognitive decline after ischaemic stroke

Michele Veldsman, Hsiao-Ju Cheng, Fang Ji, Emilio Werden, Mohamed Salah Khlif, Kwun Kei Ng, Joseph KW Lim, Xing Qian, Haoyong Yu, Juan Helen Zhou, Amy Brodtmann



Over one-third of stroke patients has long-term cognitive impairment. The likelihood of cognitive dysfunction is poorly predicted by the location or size of the infarct. The macro-scale damage caused by ischaemic stroke is relatively localized, but the effects of stroke occur across the brain. Structural covariance networks represent voxelwise correlations in cortical morphometry. Atrophy and topographical changes within such distributed brain structural networks may contribute to cognitive decline after ischaemic stroke, but this has not been thoroughly investigated. We examined longitudinal changes in structural covariance networks in stroke patients and their relationship to domain-specif..

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Awarded by National Medical Research Council, Singapore

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was supported by the National Medical Research Council, Singapore (NMRC/CIRG/1390/2014 and NMRC0088/2015), and the Duke-National University of Singapore Medical School Signature Research Program funded by Ministry of Health, Singapore (J.H.Z.) and National Health and Medical Research Council project grant (GNT1020526), the Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation (A.B.) as well as The Royal Society Commonwealth Science Conference Follow-On Grant (M.V.).