Journal article

Case Report: F-18-MK6240 Tau Positron Emission Tomography Pattern Resembling Chronic Traumatic Encephalopathy in a Retired Australian Rules Football Player

Natasha Krishnadas, Vincent Dore, Fiona Lamb, Colin Groot, Paul McCrory, Rodney Guzman, Rachel Mulligan, Kun Huang, Meaghan O'Donnell, Jennie Ponsford, Malcolm Hopwood, Victor L Villemagne, Christopher C Rowe

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Introduction: It remains unclear if tau imaging may assist diagnosis of chronic traumatic encephalopathy (CTE). Flortaucipir PET has shown superior frontal with medial temporal tau binding consistent with the provisional neuropathological criteria for mid-stage CTE in group-level analyses of retired symptomatic NFL players and in one individual with pathologically confirmed CTE. 18F-MK6240 is a new PET ligand that has high affinity for tau. We present the case of a 63-year-old cognitively impaired, former Australian rules football player with distinct superior frontal and medial temporal 18F-MK6240 binding and show it to be significantly different to the pattern seen in prodromal Alzheimer's..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC APP1127007). NK was supported by a cofunded PhD scholarship from Australian Rotary Health/Bartolina Peluso.