The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders

E Ringin; V Cropley; A Zalesky; J Bruggemann; S Sundram; CS Weickert; TW Weickert; CA Bousman; C Pantelis; TE Van Rheenen

Journal article

The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders

E Ringin, V Cropley, A Zalesky, J Bruggemann, S Sundram, CS Weickert, TW Weickert, CA Bousman, C Pantelis, TE Van Rheenen

Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2022

DOI: 10.1017/S0033291720005152

Abstract

Background: Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. Chronic cigarette smoking is prevalent in schizophrenia spectrum disorders (SSD), but the effects of smoking status on the brain and cognition in SSD are not clear. This study aimed to understand whether cognitive performance and brain morphology differed between smoking and non-smoking individuals with SSD compared to healthy controls. Methods: Data were obtained from the Australian Schizophrenia Research Bank. Cognitive functioning was measured in 299 controls and 455 SSD patients. Cortical volume, thickness and surface area data were analysed from T1-weighted st..

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University of Melbourne Researchers

Elysha Ringin Author

Vanessa Cropley Author

Andrew Zalesky Author

Christos Pantelis Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

Dr Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (1088785). Dr Cropley was supported by an NHMRC Investigator Grant (1177370) and a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660). Dr Zalesky was supported by an NHMRC Fellowship (1047648). Dr Bousman was supported by the Alberta Children's Hospital Foundation. Professor Shannon Weickert was supported by an NHMRC Senior Principal Research Fellowship (1117079), the Schizophrenia Research Institute (using infrastructure from the New South Wales Ministry of Health and the Macquarie Group Foundation), the University of New South Wales and Neuroscience Research Australia. Professor Pantelis was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825) and by a NARSAD Distinguished Investigator Award. None of the funding sources played any role in the study design; in the collection, analysis or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication