Aberrant Metabolic Patterns Networks in Insular Epilepsy
Baotian Zhao, Caio Seguin, Lin Ai, Tao Sun, Wenhan Hu, Chao Zhang, Xiu Wang, Chang Liu, Yao Wang, Jiajie Mo, Andrew Zalesky, Kai Zhang, Jianguo Zhang
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2020
Introduction: Insular epilepsy is clinically challenging. This study aimed to map cerebral metabolic networks in insular epilepsy and investigate their graph-theoretic properties, with the goal of elucidating altered metabolic network architectures that underlie interictal hypometabolism. Aims: Fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) imaging was performed in 17 individuals with a stereoelectroencephalography (SEEG) confirmed diagnosis of insula epilepsy and 14 age- and sex-matched healthy comparison individuals. Metabolic covariance networks were mapped for each group and graph theoretical analyses of these networks were undertaken. For each pair of regions ..View full abstract
Awarded by National Natural Science Foundation of China
Awarded by Beijing Municipal Science & Technology Commission
This work was sponsored by the National Natural Science Foundation of China (No. 82071457, 81771399, 81641053, and 81701276) and the Beijing Municipal Science & Technology Commission (Z171100001017069).