Journal article

How the Toxin got its Toxicity

Timothy NW Jackson, Ivan Koludarov

FRONTIERS IN PHARMACOLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Venom systems are functional and ecological traits, typically used by one organism to subdue or deter another. A predominant subset of their constituent molecules-"toxins"-share this ecological function and are therefore molecules that mediate interactions between organisms. Such molecules have been referred to as "exochemicals." There has been debate within the field of toxinology concerning the evolutionary pathways leading to the "recruitment" of a gene product for a toxic role within venom. We review these discussions and the evidence interpreted in support of alternate pathways, along with many of the most popular models describing the origin of novel molecular functions in general. We ..

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Grants

Awarded by German Research Foundation (DFG)


Funding Acknowledgements

IK was funded by the German Research Foundation (DFG), grant RE3454/6-1. TJ was supported by a grant from the National Health and Medical Research Council (NHMRC) to the Australian Venom Research Unit.