Journal article

Characterizing human safety learning via Pavlovian conditioned inhibition

Patrick AF Laing, Bram Vervliet, Miquel Angel Fullana, Hannah S Savage, Christopher G Davey, Kim L Felmingham, Ben J Harrison

BEHAVIOUR RESEARCH AND THERAPY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

Deficient safety learning has been implicated in the pathogenesis of anxiety disorders. Despite increased translational interest, there has been limited research on the basis of safety learning in humans. Here, we examined safety learning in seventy-three healthy participants via a modified Pavlovian conditioned inhibition paradigm, featuring a conditioned threat stimulus that was reinforced alone (A+), but not when combined with a second stimulus (the conditioned inhibitor, AX-). During a test phase, X and a control safety cue (C) were combined with a second threat stimulus to assess their inhibition of threat responses, measured via skin conductance (SCRs) and US-expectancy ratings. Both s..

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Grants

Awarded by Australian National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

The authors gratefully acknowledge Ms Lisa Incerti for her contributions to data collection. This study was supported by Australian National Health and Medical Research Council of Australia (NHMRC) Project Grant 1161897 (BJH, CGD, MAF, PAFL). BJH and CGD were supported by NHMRC Career Development Fellowships (1124472 and 1061757, respectively).