Journal article

White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation

Akram Zamani, Terence J O'Brien, Jeff Kershaw, Leigh A Johnston, Bridgette D Semple, David K Wright

Brain Imaging and Behavior: an international journal | Springer (part of Springer Nature) | Published : 2021


Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a young age can have devastating consequences in later life. However, how pTBI affects brain development, including white matter maturation, is still poorly understood. Here, we used advanced diffusion weighted imaging (DWI) to assess chronic white matter changes after experimental pTBI. Mice at post-natal day 21 sustained a TBI using the controlled cortical impact model and magnetic resonance imaging (MRI) was performed at 6 months post-injury using a 4.7 T Bruker scanner. Four diffusion shells with 81 directions and b-values of 1000, 3000, 5000, and 7000s/mm2 were ..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council to BS [R. D. Wright Biomedical Career Development Fellowship, number: 1141347; Project grant, number: 1122456] and to DKW [Investigator grant, number: 1174040].