Successful identification of predictive profiles for infection utilising systems-level immune analysis: a pilot study in patients with relapsed and refractory multiple myeloma
Marcel Doerflinger, Alexandra L Garnham, Saskia Freytag, Simon J Harrison, H Miles Prince, Hang Quach, Monica A Slavin, Marc Pellegrini, Benjamin W Teh
CLINICAL & TRANSLATIONAL IMMUNOLOGY | WILEY | Published : 2021
Objectives: Patients with multiple myeloma (MM) are at increased risk for infection. Clinical assessment of infection risk is increasingly challenging in the era of immune-based therapy. A pilot systems-level immune analysis study to identify predictive markers for infection was conducted. Methods: Patients with relapsed and/or refractory MM (RRMM) who participated in a treatment trial of lenalidomide and dexamethasone were evaluated. Data on patient demographics, disease and episodes of infection were extracted from clinical records. Peripheral blood mononuclear cells (PBMCs) collected at defined intervals were analysed, with or without mitogen re-stimulation, using RNA sequencing and mass ..View full abstract
Awarded by NHMRC
We thank Dr Stefanie Eggers and Maelle Le Moing from the MCRI Translational Genomics Unit for performing RNA sequencing runs. BWT is supported by a National Health and Medical Research Council Early Career Fellowship and Peter MacCallum Cancer Centre Foundation Partners Fellowship. MD has received support by the Jack Brockhoff Foundation, the CASS Foundation and the Scobie and Claire MacKinnon Trust. MP is supported by an NHMRC Investigator grant GNT1175011.