Journal article

Prolonged elevation of serum neurofilament light after concussion in male Australian football players

Stuart J McDonald, William T O'Brien, Georgia F Symons, Zhibin Chen, Jesse Bain, Brendan P Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz

BIOMARKER RESEARCH | BMC | Published : 2021


BACKGROUND: Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of serum levels of neurofilament light (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), glial fibrillary acidic protein (GFAP), and tau in concussed male and female Australian footballers. METHODS: Blood was collected from 28 Australian rules footballers (20 males, 8 females) at 2-, 6-, and 13-days after a diagnosed concussion for comparison to their levels at baseline (i.e. pre-season), and with 27 control players (19 males, 8 females) without a diagn..

View full abstract