Prolonged elevation of serum neurofilament light after concussion in male Australian football players
Stuart J McDonald, William T O'Brien, Georgia F Symons, Zhibin Chen, Jesse Bain, Brendan P Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J O'Brien, Sandy R Shultz
Biomarker Research | BMC | Published : 2021
Abstract Background Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of serum levels of neurofilament light (NfL), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), glial fibrillary acidic protein (GFAP), and tau in concussed male and female Australian footballers. Methods Blood was collected from 28 Australian rules footballers (20 males, 8 females) at 2-, 6-, and 13-days after a diagnosed concussion for comparison to their levels at baselin..View full abstract
This project was funded by grants and fellowships awarded to SRS, RM, and TOB by the Australian National Health and Medical Research Council.