Journal article

Reduced renal function may explain the higher prevalence of hyperuricemia in older people

Yutang Wang, Wanlin Zhang, Tingting Qian, Hui Sun, Qun Xu, Xujuan Hou, Wenqi Hu, Guang Zhang, Grant R Drummond, Christopher G Sobey, Fadi J Charchar, Jonathan Golledge, Guang Yang

Scientific Reports | NATURE RESEARCH | Published : 2021

Abstract

This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia prevalence in older people. A cohort of 13,288 Chinese people aged between 40 and 95 years were recruited from January to May 2019. Serum uric acid concentration and estimated glomerular filtration rate [eGFR] were measured. The associations between age or eGFR and serum uric acid or hyperuricemia were analyzed using linear or binary logistic regression adjusting for risk factors. Uric acid concentration and prevalence of hyperuricemia were greater in older participants. Adjustment for reduced renal function (eGFR < 60 mL/min/1.73 m2) eliminated the associations between older age and higher uric a..

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University of Melbourne Researchers

Grants

Awarded by Shandong Natural Fund, Shandong Province, China


Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

This work was funded by Shandong Natural Fund (ZR2015HL008), Shandong Province, China. Yutang Wang is supported by a grant from the National Health and Medical Research Council of Australia (1062671). JG holds a Practitioner Fellowship and CGS holds a Senior Research Fellowship from the National Health and Medical Research Council of Australia (NHMRC; 1117061). JG also holds a Senior Clinical Research Fellowship from the Queensland Government, Australia.