Journal article

Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large randomised control trial

JA Dubowitz, JP Cata, AP De Silva, S Braat, D Shan, K Yee, F Hollande, O Martin, EK Sloan, B Riedel

Anaesthesia | WILEY | Published : 2021

Abstract

Published data suggest that the type of general anaesthesia used during surgical resection for cancer may impact on patient long-term outcome. However, robust prospective clinical evidence is essential to guide a change in clinical practice. We explored the feasibility of conducting a randomised controlled trial to investigate the impact of total intravenous anaesthesia with propofol vs. inhalational volatile anaesthesia on postoperative outcomes of patients undergoing major cancer surgery. We undertook a randomised, double-blind feasibility and pilot study of propofol total intravenous anaesthesia or volatile-based maintenance anaesthesia during cancer resection surgery at three tertiary ho..

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Funding Acknowledgements

The authors would like to thank E. Crone and K. Coleman for assistance with patient recruitment and data collection. This study obtained ethics approval from the institutional review boards at Peter MacCallum Cancer Centre, Australia and University of Texas M.D. Anderson Cancer Center, USA. This trial was prospectively registered with ANZCTR (ACTRN12617001065381) and (NCT04316013). The work was funded by the Australian and New Zealand College of Anaesthetists Foundation and the National Health and Medical Research Council. These funding bodies played no other role in the study. JD is funded by Monash University PhD and ANZCA scholarships. No other competing interests declared.