Journal article

History of lower-limb complications and risk of cancer death in people with type 2 diabetes

Kamel Mohammedi, Stephen Harrap, Giuseppe Mancia, Michel Marre, Neil Poulter, John Chalmers, Mark Woodward

Cardiovascular Diabetology | BMC | Published : 2021

Abstract

BACKGROUND: Individuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, but uncertainties remain in terms of cancer-related death in this population. We investigated this relationship in a large cohort of people with type 2 diabetes. METHODS: We used data from the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. The primary outcome was adjudicated cancer death; secondary outcomes were overall and site-specific incident cancers, determined according to the International Classification of Diseases Code (ICD-10). We compared outcomes in individuals with (versus without)..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

The ADVANCE trial was funded by grants from the National Health and Medical Research Council (NHMRC) of Australia and Servier. MW is supported by grants 1080206 and 1149987 from the National Health and Medical Research Council (NHMRC) of Australia.