Journal article

Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction.

Iain Currie, Brad E Sleebs

Organic Letters | Published : 2021

Abstract

A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended to include the synthesis of imidodiphosphates and the natural product Microcin C.

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