The effect of HIV infection on paediatric bacterial meningitis in Blantyre, Malawi.
EM Molyneux, M Tembo, K Kayira, L Bwanaisa, J Mweneychanya, A Njobvu, H Forsyth, S Rogerson, AL Walsh, ME Molyneux
Archives of Disease in Childhood | Published : 2003
AIM: To compare presentation, progress, and outcome of acute bacterial meningitis in HIV seropositive and seronegative children. METHODS: A double blind randomised placebo controlled study of the use of dexamethasone as adjuvant therapy in acute bacterial meningitis, in children aged 2 months to 13 years, was carried out from July 1997 to March 2001. A total of 598 children were enrolled, of whom 459 were tested for HIV serostatus. RESULTS: Of the 459 children, 34% were HIV seropositive. Their presentation was similar to HIV seronegative children but more were shocked on arrival at hospital (33/157 v 12/302), and more had a focus of infection (85/157 v 57/302). HIV positive children had a hi..View full abstract