Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial.
EM Molyneux, AL Walsh, H Forsyth, M Tembo, J Mwenechanya, K Kayira, L Bwanaisa, A Njobvu, S Rogerson, G Malenga
The Lancet | Published : 2002
BACKGROUND: Steroids are used as adjuvant treatment in childhood pyogenic meningitis to attenuate host inflammatory responses to bacterial invasion. We aimed to assess the effectiveness of dexamethasone in management of acute bacterial meningitis in a developing country. METHODS: In a double-blind, placebo controlled trial, we included 598 children with pyogenic meningitis who had been admitted to the children's wards of the Queen Elizabeth Central Hospital, Blantyre, Malawi. We did physical, neurological, developmental, and hearing assessments at 1 and 6 months after discharge. The primary outcome was overall death. Secondary outcomes included sequelae, in-hospital deaths, and death after d..View full abstract