Journal article

Associations Between Fetal Growth Trajectories and the Development of Myopia by 20 Years of Age

Kathleen IC Dyer, Paul G Sanfilippo, Scott W White, Jeremy A Guggenheim, Chris J Hammond, John P Newnham, David A Mackey, Seyhan Yazar

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2020


Purpose: To evaluate the contribution of genetic and early life environmental factors, as reflected by fetal anthropometric growth trajectories, toward the development of myopia during childhood and adolescence. Methods: This analysis included 498 singleton Caucasian participants from the Raine Study, a pregnancy cohort study based in Western Australia. Serial fetal biometric measurements of these participants were collected via ultrasound scans performed at 18, 24, 28, 34, and 38 weeks' gestation. At a 20-year follow-up, the participants underwent a comprehensive ophthalmic examination, including cycloplegic autorefraction and ocular biometry measurements. Using a group-based trajectory mod..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The eye data collection for the Gen2-20 year follow-up of the Raine Study was funded by the Australian National Health and Medical Research Council (NHMRC) (grant 1021105), the Ophthalmic Research Institute of Australia, the Alcon Research Institute, the Lions Eye Institute, and the Australian Foundation for the Prevention of Blindness. The core management of the Raine Study is funded by the University of Western Australia, Curtin University, Telethon Kids Institute, Women and Infants Research Foundation, Edith Cowan University, Murdoch University, the University of Notre Dame Australia, and the Raine Medical Research Foundation. The funding organizations had no role in the design or conduct of this research. SY is supported by a NHMRC Early Career Fellowship. DAM is supported by a NHMRC Practitioner Fellowship.