Relationship between QT interval prolongation and structural abnormalities in cirrhotic cardiomyopathy: A change in the current paradigm
Anoop N Koshy, Paul J Gow, Adam Testro, Andrew W Teh, Jefferson Ko, Han S Lim, Hui-Chen Han, Laurence Weinberg, Lisa B VanWagner, Omar Farouque
AMERICAN JOURNAL OF TRANSPLANTATION | WILEY | Published : 2021
It is postulated that cardiac structural abnormalities observed in cirrhotic cardiomyopathy (CCM) contribute to the electrophysiologic abnormality of QT interval (QTc) prolongation. We sought to evaluate whether QTc prolongation is associated with intrinsic abnormalities in cardiac structure and function that characterize CCM. Consecutive patients undergoing liver transplant work-up between 2010 and 2018 were included. Measures of cardiac function on stress testing including cardiac reserve and chronotropic incompetence were collected prospectively and a corrected QTc ≥ 440 ms was considered prolonged. Overall, 439 patients were included and 65.1% had a prolonged QTc. There were no differenc..View full abstract
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Awarded by Royal Australasian College of Physicians Blackburn Scholarship
Dr Anoop N Koshy is a recipient of the National Health and Medical Research Council of Australia/National Heart Foundation Post-Graduate Scholarship and Royal Australasian College of Physicians Blackburn Scholarship (1150874).