Journal article

Emerging benefits and drawbacks of alpha(2)-adrenoceptor agonists in the management of sepsis and critical illness

Yugeesh R Lankadeva, Yahya Shehabi, Adam M Deane, Mark P Plummer, Rinaldo Bellomo, Clive N May

BRITISH JOURNAL OF PHARMACOLOGY | WILEY | Published : 2021

Abstract

Agonists of α2 -adrenoceptors are increasingly being used for the provision of comfort, sedation and the management of delirium in critically ill patients, with and without sepsis. In this context, increased sympathetic and inflammatory activity are common pathophysiological features linked to multi-organ dysfunction, particularly in patients with sepsis or those undergoing cardiac surgery requiring cardiopulmonary bypass. Experimental and clinical studies support the notion that the α2 -adrenoceptor agonists, dexmedetomidine and clonidine, mitigate sympathetic and inflammatory overactivity in sepsis and cardiac surgery requiring cardiopulmonary bypass. These effects can protect vital organs..

View full abstract