Journal article

Are troponin and B-type natriuretic peptides useful biomarkers for the diagnosis of systemic sclerosis heart involvement? A systematic literature review

Laura Ross, Jayne Moxey, Mandana Nikpour

SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2021

Abstract

BACKGROUND: Systemic sclerosis (SSc) heart involvement (SHI) is a leading cause of SSc-associated mortality and once clinically overt, carries a very poor prognosis. There remain no established diagnostic criteria for SHI. This study aimed to systematically review the literature regarding the role of cardiac troponin (cTn) and B-type natriuretic peptide (BNP) or N-terminal B-type natriuretic peptide (NT-proBNP) in the diagnosis of SHI. METHODS: A comprehensive search of the MEDLINE (Ovid), EMBASE and Pubmed databases was performed to identify adult human studies of at least 10 SSc patients with a primary focus of SHI that included data on cTn and BNP or NT-proBNP results. Only cohort studies..

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Grants

Awarded by National Health and Medical Research Council of Australia Investigator Grant


Funding Acknowledgements

LR is supported by a MSK Australia PhD scholarship and an Australian Government Research Training Program Scholarship. MN holds a National Health and Medical Research Council of Australia Investigator Grant (APP 1176538).