Journal article
Damage Trajectories in Systemic Sclerosis Using Group-Based Trajectory Modeling
Ariane Barbacki, Murray Baron, Mianbo Wang, Yuqing Zhang, Wendy Stevens, Joanne Sahhar, Susanna Proudman, Mandana Nikpour, Ada Man
Arthritis Care and Research | Wiley | Published : 2023
DOI: 10.1002/acr.24873
Abstract
OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive organ damage, which can be measured using the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI). We aimed to identify whether distinct trajectories of damage accrual exist and to determine which variables are associated with different trajectory groups. METHODS: Incident cases of SSc (<2 years) were identified in the Australian Scleroderma Interest Group and Canadian Scleroderma Research Group prospective registries. Group-based trajectory modeling was used to identify SCTC-DI trajectories over the cohort's first 5 annual visits. Baseline variables associated with trajectory membership in..
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Awarded by National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant
Funding Acknowledgements
The Australian Scleroderma Interest Group is supported by Scleroderma Victoria and Scleroderma Australia and has received research grants from Janssen, GlaxoSmithKline, the Australian Rheumatology Association (Arthritis Australia), and St. Vincent's Hospital Melbourne Research Endowment Fund. The Canadian Scleroderma Research Group is supported by the Canadian Institutes of Health Research, Scleroderma Canada, the Scleroderma Society of Ontario, the Scleroderma Association of Saskatchewan, Scleroderma Manitoba, the Scleroderma Society of Nova Scotia, the Scleroderma Association of British Columbia, the Cure Scleroderma Foundation, the Canadian Blood and Marrow Transplant Group, and the Lady Davis Institute of Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada. The CSRG has received educational grants from Actelion pharmaceuticals and Mallinckrodt. Dr. Nikpour is recipient of a National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant (grant GNT 1176538).