Journal article

The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited

Matthew P Deek, Kim Van der Eecken, Ryan Phillips, Neil R Parikh, Pedro Isaacsson Velho, Tamara L Lotan, Amar U Kishan, Tobias Maurer, Paul C Boutros, Christopher Hovens, Matthew Abramowtiz, Alan Pollack, Neil Desai, Bradley Stish, Felix Y Feng, Mario Eisenberger, Michael Carducci, Kenneth J Pienta, Mark Markowski, Channing J Paller Show all

EUROPEAN UROLOGY | ELSEVIER | Published : 2021

Abstract

BACKGROUND: Emerging data suggest that metastasis is a spectrum of disease burden rather than a binary state, and local therapies, such as radiation, might improve outcomes in oligometastasis. However, current definitions of oligometastasis are solely numerical. OBJECTIVE: To characterize the somatic mutational landscape across the disease spectrum of metastatic castration-sensitive prostate cancer (mCSPC) to elucidate a biological definition of oligometastatic CSPC. DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective study of men with mCSPC who underwent clinical-grade sequencing of their tumors (269 primary tumor, 25 metastatic sites). Patients were classified as having biochemical..

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Grants

Awarded by NIH/NCI


Funding Acknowledgements

PT Tran recieved support from Ronald Rose and Joan Lazar, Nesbitt-McMaster Foundation, Barbara's Fund, National Capital Cancer Research Fund, Prostate Cancer Foundation, Movember Foundation and the NIH/NCI (U01CA212007, U01CA231776 and R21CA223403).