Journal article
The Mutational Landscape of Metastatic Castration-sensitive Prostate Cancer: The Spectrum Theory Revisited
MP Deek, K Van der Eecken, R Phillips, NR Parikh, P Isaacsson Velho, TL Lotan, AU Kishan, T Maurer, PC Boutros, C Hovens, M Abramowtiz, A Pollack, N Desai, B Stish, FY Feng, M Eisenberger, M Carducci, KJ Pienta, M Markowski, CJ Paller Show all
European Urology | ELSEVIER | Published : 2021
Abstract
Background: Emerging data suggest that metastasis is a spectrum of disease burden rather than a binary state, and local therapies, such as radiation, might improve outcomes in oligometastasis. However, current definitions of oligometastasis are solely numerical. Objective: To characterize the somatic mutational landscape across the disease spectrum of metastatic castration-sensitive prostate cancer (mCSPC) to elucidate a biological definition of oligometastatic CSPC. Design, setting, and participants: This was a retrospective study of men with mCSPC who underwent clinical-grade sequencing of their tumors (269 primary tumor, 25 metastatic sites). Patients were classified as having biochemical..
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Awarded by National Institutes of Health
Funding Acknowledgements
PT Tran recieved support from Ronald Rose and Joan Lazar, Nesbitt-McMaster Foundation, Barbara's Fund, National Capital Cancer Research Fund, Prostate Cancer Foundation, Movember Foundation and the NIH/NCI (U01CA212007, U01CA231776 and R21CA223403).