Conference Proceedings
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
TS Ahluwalia, BP Prins, M Abdollahi, NJ Armstrong, S Aslibekyan, L Bain, B Jefferis, J Baumert, M Beekman, Y Ben-Shlomo, JC Bis, BD Mitchell, E De Geus, GE Delgado, D Marek, J Eriksson, E Kajantie, S Kanoni, JP Kemp, C Lu Show all
Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2021
DOI: 10.1093/hmg/ddab023
Abstract
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-A nd anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 ..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
Novo Nordisk Foundation (NNF18OC0052457 to T.S.A.). Detailed Funding statements from participating study cohorts can be found in Supplementary Material, Table S12.