Genome-wide association study of circulating interleukin 6 levels identifies novel loci
Tarunveer S Ahluwalia, Bram P Prins, Mohammadreza Abdollahi, Nicola J Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, Jens Baumert, Marian Beekman, Yoav Ben-Shlomo, Joshua C Bis, Braxton D Mitchell, Eco de Geus, Graciela E Delgado, Diana Marek, Joel Eriksson, Eero Kajantie, Stavroula Kanoni, John P Kemp, Chen Lu Show all
HUMAN MOLECULAR GENETICS | OXFORD UNIV PRESS | Published : 2021
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 ..View full abstract
Awarded by Novo Nordisk Foundation
Novo Nordisk Foundation (NNF18OC0052457 to T.S.A.). Detailed Funding statements from participating study cohorts can be found in Supplementary Material, Table S12.