Journal article

beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2021

Abstract

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. ACEi and ARBs have been shown to abolish inflammation and redox stress but only partially restore endothelial function in mesenteric vessels. We investigated whether sympatho-adrenal overactivation evokes coronary vascular dysfunction when a high salt intake is combined with insulin resistance in male Goto-Kakizaki (GK) and Wistar rats treated with two different classes of beta-blocker or vehicle, utilising synchrotron based microangiography in vivo. Further, we examined if chronic carvedilol (CAR) treatment preserves nit..

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Grants

Awarded by National Health and Medical Research Council


Awarded by International Synchrotron Access Program


Awarded by Intramural Research Funds of the National Cerebral and Cardiovascular Center


Awarded by JSPS KAKENHI


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Senior Research Fellowship and Programme grant [grant number 1092642 (to D.J.K.)]; travel funded by the International Synchrotron Access Program [grant number ISAP, AS/IA131] managed by the Australian Synchrotron, part of ANSTO, and funded by the Australian Government; the Intramural Research Funds [grant numbers 22-2-3, 22-3-2] of the National Cerebral and Cardiovascular Center; and the JSPS KAKENHI [grant number 19H03405].