Journal article

Maternal and Cord Blood 25-Hydroxyvitamin D-3 Are Associated with Increased Cord Blood and Naive and Activated Regulatory T Cells: The Barwon Infant Study

Steffen U Thorsen, Fiona Collier, Angela Pezic, Martin O'Hely, Michael Clarke, Mimi LK Tang, David Burgner, Peter Vuillermin, Anne-Louise Ponsonby

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2021

Abstract

Vitamin D has shown immune-modulatory effects but mostly in in vitro and animal studies. Regulatory T cells (Treg) are important for a balanced immune system. The relationship between vitamin D on the number of circulating neonatal Treg is unclear. We sought to investigate the association between maternal and neonatal vitamin D metabolites and cord blood (CB) Treg subsets. In a cohort of Australian infants (n = 1074), recruited using an unselected antenatal sampling frame, 158 mother-infant pairs had data on the following: 1) 25-hydroxyvitamin D3 (25(OH)D3) measures in both maternal peripheral blood (28- to 32-wk gestation) and infant CB; 2) proportions (percentage of CD4+ T cells) of CB Tre..

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Grants

Funding Acknowledgements

This work was supported by Murdoch Children's Research Institute and in part by the Department of Health/National Health and Medical Research Council, Deakin University, the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the OurWomen's Our Children's Fund Raising Committee/Barwon Health, the Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, the Percy Baxter Charitable Trust, and Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.