Journal article
Maternal and cord blood 25-hydroxyvitamin D3 are associated with increased cord blood and naive and activated regulatory T cells: The Barwon infant study
SU Thorsen, F Collier, A Pezic, M O’Hely, M Clarke, MLK Tang, D Burgner, P Vuillermin, AL Ponsonby, J Carlin, T Dwyer, S Ranganathan, P Sly, L Harrison
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2021
Abstract
Vitamin D has shown immune-modulatory effects but mostly in in vitro and animal studies. Regulatory T cells (Treg) are important for a balanced immune system. The relationship between vitamin D on the number of circulating neonatal Treg is unclear. We sought to investigate the association between maternal and neonatal vitamin D metabolites and cord blood (CB) Treg subsets. In a cohort of Australian infants (n = 1074), recruited using an unselected antenatal sampling frame, 158 mother–infant pairs had data on the following: 1) 25-hydroxyvitamin D3 (25(OH)D3) measures in both maternal peripheral blood (28- to 32-wk gestation) and infant CB; 2) proportions (percentage of CD4+ T cells) of CB Tre..
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Funding Acknowledgements
This work was supported by Murdoch Children's Research Institute and in part by the Department of Health/National Health and Medical Research Council, Deakin University, the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the OurWomen's Our Children's Fund Raising Committee/Barwon Health, the Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited, the Percy Baxter Charitable Trust, and Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program.