Journal article

Associations between diet, the gut microbiome and short chain fatty acids in youth with islet autoimmunity and type 1 diabetes

Jessica E Harbison, Rebecca L Thomson, John M Wentworth, Jennie Louise, Alexandra Roth-Schulze, Rachel J Battersby, Katrina M Ngui, Megan AS Penno, Peter G Colman, Maria E Craig, Simon C Barry, Cuong D Tran, Maria Makrides, Leonard C Harrison, Jennifer J Couper

Pediatric Diabetes | WILEY | Published : 2021

Abstract

AIM: We aimed to characterize associations between diet and the gut microbiome and short chain fatty acid (SCFA) products in youth with islet autoimmunity or type 1 diabetes (IA/T1D) in comparison with controls. RESEARCH DESIGN AND METHODS: Eighty participants (25 diagnosed with T1D, 17 with confirmed IA, 38 sibling or unrelated controls) from the Australian T1D Gut Study cohort were studied (median [IQR] age 11.7 [8.9, 14.0] years, 43% female). A Food Frequency Questionnaire characterized daily macronutrient intake over the preceding 6 months. Plasma and fecal SCFA were measured by gas chromatography; gut microbiome composition and diversity by 16S rRNA gene sequencing. RESULTS: A 10 g incr..

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Grants

Funding Acknowledgements

Australian Research Council; Channel 7 Children's Research Foundation; Diabetes South Australia; Juvenile Diabetes Research Foundation Australia; Juvenile Diabetes Research Foundation United States of America; Leona M. and Harry B. Helmsley Charitable Trust; National Health and Medical Research Council; Pfizer Australasian Paediatric Endocrine Care