Journal article
Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
Julie A Pasco, Amanda L Stuart, Sophia X Sui, Kara L Holloway-Kew, Natalie K Hyde, Monica C Tembo, Pamela Rufus-Membere, Mark A Kotowicz, Lana J Williams
JOURNAL OF CLINICAL MEDICINE | MDPI | Published : 2021
DOI: 10.3390/jcm10020173
Abstract
Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51-87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < -1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and l..
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Awarded by National Health and Medical Research Council (NHMRC), Australia
Awarded by NHMRC Career Development Fellowship
Awarded by NHMRC Investigator grant
Funding Acknowledgements
The Geelong Osteoporosis Study was funded by the National Health and Medical Research Council (NHMRC), Australia (projects 251638, 628582). S.X.S., M.C.T., and P.R.M. were supported by Deakin Postgraduate Scholarships; K.L.H.-K. was supported by an Alfred Deakin Postdoctoral Research Fellowship; N.K.H. was supported by a Deakin Postdoctoral Research Fellowship; and L.J.W. was supported by a NHMRC Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060). However, these funding organisations played no role in the design and conduct of the study, in the collection, management, analysis and interpretation of the data, or in the preparation, review, and approval of the manuscript.