Association between pre-treatment perfusion profile and cerebral edema after reperfusion therapies in ischemic stroke

FC Ng; L Churilov; N Yassi; TJ Kleinig; V Thijs; TY Wu; D Shah; HM Dewey; G Sharma; PM Desmond; B Yan; MW Parsons; GA Donnan; SM Davis; PJ Mitchell; BCV Campbell

Conference Proceedings

Association between pre-treatment perfusion profile and cerebral edema after reperfusion therapies in ischemic stroke

FC Ng, L Churilov, N Yassi, TJ Kleinig, V Thijs, TY Wu, D Shah, HM Dewey, G Sharma, PM Desmond, B Yan, MW Parsons, GA Donnan, SM Davis, PJ Mitchell, BCV Campbell

Journal of Cerebral Blood Flow and Metabolism | SAGE PUBLICATIONS INC | Published : 2021

DOI: 10.1177/0271678X211017696

Abstract

The relationship between reperfusion and edema is unclear, with experimental and clinical data yielding conflicting results. We investigated whether the extent of salvageable and irreversibly-injured tissue at baseline influenced the effect of therapeutic reperfusion on cerebral edema. In a pooled analysis of 415 patients with anterior circulation large vessel occlusion from the Tenecteplase-versus-Alteplase-before-Endovascular-Therapy-for-Ischemic-Stroke (EXTEND-IA TNK) part 1 and 2 trials, associations between core and mismatch volume on pre-treatment CT-Perfusion with cerebral edema at 24-hours, and their interactions with reperfusion were tested. Core volume was associated with increased..

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University of Melbourne Researchers

Leonid Churilov Author

Nawaf Yassi Author

Vincent Thijs Author

Patricia Desmond Author

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Grants

Awarded by Amgen

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is supported by grants from the National Health and Medical Research Council of Australia (1043242, 1035688, 1113352, 1111972, 1150610), National Heart Foundation of Australia (100782), State Government of Victoria and the Australian and New Zealand Association of Neurologist. The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.