Journal article

Unraveling the Consequences of Childhood Maltreatment: Deviations From Typical Functional Neurodevelopment Mediate the Relationship Between Maltreatment History and Depressive Symptoms

Divyangana Rakesh, Clare Kelly, Nandita Vijayakumar, Andrew Zalesky, Nicholas B Allen, Sarah Whittle

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING | ELSEVIER | Published : 2021

Abstract

BACKGROUND: Childhood maltreatment is associated with lifelong psychiatric sequelae. However, our understanding of neurobiological mechanisms responsible for this association is limited. Childhood maltreatment may confer risk for psychopathology by altering neurodevelopmental trajectories during childhood and adolescence. Longitudinal research, which is essential for examining this question, has been limited. METHODS: We investigated maltreatment-associated alterations in the development of neural circuitry. Associations between cumulative childhood maltreatment (assessed using a dimensional measure of abuse and neglect via the Childhood Trauma Questionnaire) and the longitudinal development..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Australian Research Council


Funding Acknowledgements

This work was supported by the Colonial Foundation, National Health and Medical Research Council (NHMRC) (Program Grant No. 350241, Senior Research Fellowship Grant No. 1136649 [to AZ] , and Career Development Fellowship Grant No. 1125504 [to SW] ) , Australian Research Council (Discovery Grant Nos. DP0878136 and DP1092637) , University of Melbourne Research Scholarship (to DR) , and Trinity College Dublin Pathfinder Award (to CK) .