Journal article

Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes

Frances C Taylor, David W Dunstan, Ashleigh R Homer, Paddy C Dempsey, Bronwyn A Kingwell, Rachel E Climie, Neville Owen, Neale D Cohen, Robyn N Larsen, Megan Grace, Nina Eikelis, Michael J Wheeler, Melanie K Townsend, Nirav Maniar, Daniel J Green

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2021

Abstract

In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple resistance activities (SRA) at different frequencies. In a randomized crossover trial, 24 adults with T2D (35-70 yr) completed three 7-h conditions: 1) uninterrupted sitting (SIT), 2) sitting with 3-min bouts of SRA every 30 min (SRA3), and 3) sitting with 6 min bouts of SRA every 60 min (SRA6). Femoral a..

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Grants

Awarded by Heart Foundation of Australia Vanguard grant


Awarded by National Health and Medical Research Council (NHMRC) Centre of Research Excellence grant


Funding Acknowledgements

This study was supported by a Heart Foundation of Australia Vanguard grant (No. 101506), a National Health and Medical Research Council (NHMRC) Centre of Research Excellence grant (No. 1057608; Sitting Time and Chronic Disease Prevention-Measurement, Mechanisms and Interventions), and by the Foundation of the High Blood Pressure Council of Australia Early Career Researcher and the Victorian Government Operational Infrastructure Program. D.W.D., D.J.G., P.C.D., and N.O. are supported by the NHMRC Fellowships scheme.