Speech Discrimination Tasks: A Sensitive Sensory and Cognitive Measure in Early and Mild Multiple Sclerosis
Pippa Iva, Joanne Fielding, Meaghan Clough, Owen White, Branislava Godic, Russell Martin, Ramesh Rajan
FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2020
There is a need for reliable and objective measures of early and mild symptomology in multiple sclerosis (MS), as deficits can be subtle and difficult to quantify objectively in patients without overt physical deficits. We hypothesized that a speech-in-noise (SiN) task would be sensitive to demyelinating effects on precise neural timing and diffuse higher-level networks required for speech intelligibility, and therefore be a useful tool for monitoring sensory and cognitive changes in early MS. The objective of this study was to develop a SiN task for clinical use that sensitively monitors disease activity in early (10 years) stages of MS subjects with mild severity [Expanded Disability Statu..View full abstract
The project was funded by internal lab funds from the Monash University.