Journal article

Predictors and outcomes of extubation failure in extremely preterm infants

Anna Madeline Kidman, Brett J Manley, Rosemarie A Boland, Peter G Davis, Risha Bhatia

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2021

Abstract

AIM: To determine predictors and outcomes of extubation failure in extremely preterm (EP) infants born <28 weeks' gestational age (GA). METHODS: Retrospective clinical audit across two tertiary-level neonatal intensive care units in Melbourne, Australia. Two-hundred and four EP infants who survived to their first extubation from mechanical ventilation. Extubation failure (re-intubation) within 7 days after the first extubation. RESULTS: Lower GA (odds ratio [OR] 0.71, 95% confidence interval (CI), 0.61-0.89, P < 0.001) and higher pre-extubation measured mean airway pressure (MAP) on the mechanical ventilator (OR 1.9 [95% CI 1.41-2.51], P < 0.001) predicted extubation failure. The area under ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Newborn Medicine


Awarded by Medical Research Future Fund (Australia) Next Generation Clinical Researchers Career Development Fellowship


Awarded by NHMRC


Funding Acknowledgements

The authors wish to thank the staff and families of the neonatal intensive care units at Monash Children's Hospital and The Royal Women's Hospital, Melbourne, Australia. AM Kidman is supported by a PhD scholarship from the National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Newborn Medicine (GNT1153176). BJ Manley is supported by a Medical Research Future Fund (Australia) Next Generation Clinical Researchers Career Development Fellowship (MRF1159225). RA Boland is supported by a Career Development Award from the Murdoch Children's Research Institute (2015-2020). PG Davis is supported by an NHMRC Practitioner Fellowship (1157782).