Journal article

Proteome-wide Systems Genetics to Identify Functional Regulators of Complex Traits

Jeffrey Molendijk, Benjamin L Parker

CELL SYSTEMS | CELL PRESS | Published : 2021

Abstract

Proteomic technologies now enable the rapid quantification of thousands of proteins across genetically diverse samples. Integration of these data with systems-genetics analyses is a powerful approach to identify new regulators of economically important or disease-relevant phenotypes in various populations. In this review, we summarize the latest proteomic technologies and discuss technical challenges for their use in population studies. We demonstrate how the analysis of correlation structure and loci mapping can be used to identify genetic factors regulating functional protein networks and complex traits. Finally, we provide an extensive summary of the use of proteome-wide systems genetics ..

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Grants

Awarded by Australian National Health and Medical Research Council Ideas grant


Funding Acknowledgements

This work was funded by an Australian National Health and Medical Research Council Ideas grant (APP1184363) and the University of Melbourne Driving Research Momentum program. We thank Aldons Jake Lusis from David Geffen School of Medicine at the University of California, Los Angeles, USA, for critical feedback and editing. We also thank Jane Parker for further editing.