Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach
Jessica A Hartmann, Patrick D McGorry, Louise Destree, G Paul Amminger, Andrew M Chanen, Christopher G Davey, Rachid Ghieh, Andrea Polari, Aswin Ratheesh, Hok Pan Yuen, Barnaby Nelson
Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2021
Most psychiatric disorders develop during adolescence and young adulthood and are preceded by a phase during which attenuated or episodic symptoms and functional decline are apparent. The introduction of the ultra-high risk (UHR) criteria two decades ago created a new framework for identification of risk and for pre-emptive psychiatry, focusing on first episode psychosis as an outcome. Research in this paradigm demonstrated the comorbid, diffuse nature of emerging psychopathology and a high degree of developmental heterotopy, suggesting the need to adopt a broader, more agnostic approach to risk identification. Guided by the principles of clinical staging, we introduce the concept of a pluri..View full abstract
This work is supported by a grant from the John T. Reid Charitable Trust and the Colonial Foundation. JH is supported by a University of MelbourneMcKenzie Postdoctoral Fellowship.