Journal article

Eye rubbing in the aetiology of keratoconus: a systematic review and meta-analysis

Srujana Sahebjada, Haitham H Al-Mahrouqi, Sophia Moshegov, Sathiya M Panchatcharam, Elsie Chan, Mark Daniell, Paul N Baird

Graefe's Archive for Clinical and Experimental Ophthalmology | SPRINGER | Published : 2021


PURPOSE: Keratoconus is a potentially blinding condition that slowly deforms the cornea in young people. Despite the increasing prevalence of keratoconus, the exact aetiology of the condition is unknown. This first systematic review examines the evidence of eye rubbing and its association with keratoconus and presents the findings of the meta-analysis. METHODS: Two independent reviewers searched the electronic databases for all potential articles published from 1st of January 1900 to 31st of July 2020 on eye rubbing and keratoconus. The researchers assessed the methodological quality of the studies using the Newcastle-Ottawa scale for observational studies. The assessment for statistical het..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This study was supported by the Australian National Health and Medical Research Council (NHMRC) project Ideas grant APP1187763 and Senior Research Fellowship (1138585 to PB), the Angior Family Foundation (SS), Keratoconus Australia (SS), Perpetual Impact Philanthropy grant (SS), Lions Eye Foundation Fellowship (SS), and CERA Hector MacLean Scholarship (SM). The Centre for Eye Research Australia (CERA) receives Operational Infrastructure Support from the Victorian Government.