Journal article
Residential proximity to agriculture and risk of childhood leukemia and central nervous system tumors in the Danish national birth cohort
DM Patel, S Gyldenkærne, RR Jones, SF Olsen, G Tikellis, C Granström, T Dwyer, LT Stayner, MH Ward
Environment International | Published : 2020
Open access
Abstract
Background: Living in an agricultural area or on farms has been associated with increased risk of childhood cancer but few studies have evaluated specific agricultural exposures. We prospectively examined residential proximity to crops and animals during pregnancy and risk of childhood leukemia and central nervous system (CNS) tumors in Denmark. Methods: The Danish National Birth Cohort (DNBC) consists of 91,769 pregnant women (96,841 live-born children) enrolled in 1996–2003. For 61 childhood leukemias and 59 CNS tumors 30% of the area of one or more crop. We used Cox proportional hazard models (weighted to the full cohort) to estimate hazard ratios (HR) and 95% confidence intervals (CI) fo..
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Awarded by National Cancer Institute
Funding Acknowledgements
This research was partially funded by the intramural research program of the National Cancer Institute (Project ZO1 CP01012522). The Danish National Birth Cohort was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, the Pharmacy Foundation, the Egmont Foundation, the March of Dimes Birth Defects Foundation, the Health Foundation and other minor grants.