Journal article

Suitability of a Progenitor Cell-Enriching Device for In Vitro Applications

Antonio Celentano, Tami Yap, Giuseppe Pantaleo, Rita Paolini, Michael McCullough, Nicola Cirillo

COATINGS | MDPI | Published : 2021


Rigenera® is a novel class‐1 medical device that produces micro‐grafts enriched of progenitors cells without ex vivo manipulation of donor tissues. The manufacturer’s protocol has been supported for a wide variety of clinical uses in the field of regenerative medicine. This study aimed to evaluate its potential use for in vitro cell models. Human primary oral fibroblasts were cultured under standard conditions and processed through Rigenera® over a time course of up to 5 min. Cell viability was assessed using a Trypan Blue exclusion test. It is possible to process fibroblasts through Rigenera® although an initial reduction of cell viability was observed. Additionally, debris was evident in t..

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Funding Acknowledgements

This study was funded in part by Human Brain Wave (HBW) srl, Italy. The authors wish to acknowledge the support of the Melbourne Dental School, The University of Melbourne.