Journal article

Characterization of Polycaprolactone Nanohydroxyapatite Composites with Tunable Degradability Suitable for Indirect Printing

Stephanie E Doyle, Lauren Henry, Ellen McGennisken, Carmine Onofrillo, Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Elena Pirogova

POLYMERS | MDPI | Published : 2021

Abstract

Degradable bone implants are designed to foster the complete regeneration of natural tissue after large-scale loss trauma. Polycaprolactone (PCL) and hydroxyapatite (HA) composites are promising scaffold materials with superior mechanical and osteoinductive properties compared to the single materials. However, producing three-dimensional (3D) structures with high HA content as well as tuneable degradability remains a challenge. To address this issue and create homogeneously distributed PCL-nanoHA (nHA) scaffolds with tuneable degradation rates through both PCL molecular weight and nHA concentration, we conducted a detailed characterisation and comparison of a range of PCL-nHA composites acro..

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Grants

Awarded by NHMRC-MRFF Investigator Grant


Funding Acknowledgements

This work was supported by (1) St Vincent's Hospital (Melbourne) Research Endowment Fund, (2) Victorian Medical Research Acceleration Fund (2018, Round 2), (3) NHMRC-MRFF Investigator Grant (Di Bella) #1193897 and (4) Australian Technology Network of Universities Industry Doctoral Training Centre (IDTC) scholarship.