In vitro evaluation of drug delivery behavior for inhalable amorphous nanoparticle formulations in a human lung epithelial cell model
Jianting Chen, Maizbha U Ahmed, Chune Zhu, Shihui Yu, Weisan Pan, Tony Velkov, Jian Li, Qi Tony Zhou
INTERNATIONAL JOURNAL OF PHARMACEUTICS | ELSEVIER | Published : 2021
Respiratory tract infections caused by multidrug-resistant (MDR) Gram-negative bacteria such as Pseudomonas aeruginosa are serious burdens to public health, especially in cystic fibrosis patients. The combination of colistin, a cationic polypeptide antibiotic, and ivacaftor, a cystic fibrosis transmembrane regulator (CFTR) protein modulator, displays a synergistic antibacterial effect against P. aeruginosa. The primary aim of the present study is to investigate the transport, accumulation and toxicity of a novel nanoparticle formulation containing colistin and ivacaftor in lung epithelial Calu-3 cells. The cell viability results demonstrated that ivacaftor alone or in combination with colist..View full abstract
Awarded by National Institutes of Health/National Institute of Allergy and Infectious Diseases
This study was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases (R01AI132681 and R01AI146160). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. J.C. is supported by a scholarship from China Scholarship Council.