Journal article

It's more than just interoception: The insular cortex involvement in alcohol use disorder

Erin J Campbell, Andrew J Lawrence

JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 2021

Abstract

Understanding brain structures and circuits impacted by alcohol use disorder is critical for improving our future prevention techniques and treatment options. A brain region that has recently gained traction for its involvement in substance use disorder is the insular cortex. This brain region is multi-functional and spatially complex, resulting in a relative lack of understanding of the involvement of the insular cortex in alcohol use disorder. Here we discuss the role of the insular cortex in alcohol use disorder, particularly during periods of abstinence and in response to alcohol and alcohol-related cues and contexts. We also discuss a broader role of the insular in alcohol-associated ri..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation


Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) Project Grant (Grant number 1159032). AJL is a NHMRC Principal Fellow (1116930). EJC received a Jack Brockhoff Early Career Researcher Grant (Grant number 4496-2018) and a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (Grant number 28 007). We acknowledge the Victorian State Government Operational Infrastructure Scheme.