An integrated circuit towards improved management of epilepsy and other neurological conditions

Abstract

Epilepsy is the second-most common neurological disorder, with an estimated prevalence of 1% worldwide. Antiepileptic drugs (AEDs) are the frontline treatment but, despite more than 25 agents available, there can be significant difficulties in finding a treatment plan that controls seizures without unacceptable side effects. Furthermore, approximately 30% of patients do not obtain full control of seizures with the available AEDs. Therefore, there exists a need for novel therapies. Therapeutic electrical stimulation of the brain and peripheral nervous system has shown great promise in treating those with refractory epilepsy, but still little is known about the mechanisms underlying this. Rec..