Journal article

Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis

Arnoud J Templeton, Mairéad G McNamara, Boštjan Šeruga, Francisco E Vera-Badillo, Priya Aneja, Alberto Ocaña, Raya Leibowitz-Amit, Guru Sonpavde, Jennifer J Knox, Ben Tran, Ian F Tannock, Eitan Amir

Journal of the National Cancer Institute | Oxford University Press (OUP) | Published : 2014

Abstract

BACKGROUND: Inflammation may play an important role in cancer progression, and a high neutrophil-to-lymphocyte ratio (NLR) has been reported to be a poor prognostic indicator in several malignancies. Here we quantify the prognostic impact of this biomarker and assess its consistency in solid tumors. METHODS: A systematic review of electronic databases was conducted to identify publications exploring the association of blood NLR and clinical outcome in solid tumors. Overall survival (OS) was the primary outcome, and cancer-specific survival (CSS), progression-free survival (PFS), and disease-free survival (DFS) were secondary outcomes. Data from studies reporting a hazard ratio and 95% confid..

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